解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Four major receptor families enable cells to respond to chemical and physical signals from their proximal environment. The ligand- and voltage-gated ion channels, G-protein-coupled receptors, nuclear hormone receptors, and receptor tyrosine kinases are all allosteric proteins that carry multiple, spatially distinct, y...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2016.08.015
更新日期:2016-08-25 00:00:00
abstract::We used clinical tissue from lethal metastatic castration-resistant prostate cancer (CRPC) patients obtained at rapid autopsy to evaluate diverse genomic, transcriptomic, and phosphoproteomic datasets for pathway analysis. Using Tied Diffusion through Interacting Events (TieDIE), we integrated differentially expressed...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.07.007
更新日期:2016-08-11 00:00:00
abstract::Several metabolic alterations accumulate over time along with a reduction in biological fitness, suggesting the existence of a "metabolic clock" that controls aging. Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence metabolism. Each of the...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2016.07.031
更新日期:2016-08-11 00:00:00
abstract::Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin cross-reactive memory B cells and identified three antibody classes, each capable of neutralizing di...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.06.043
更新日期:2016-07-28 00:00:00
abstract::Meyer et al. find that subjects lacking the AIRE gene, critical for self-tolerance in T lymphocytes, show a broad range of autoantibody specificities, which can have extremely high affinities. The data also suggest that some of these autoantibodies can, surprisingly, prevent some types of autoimmunity, particularly ty...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2016.07.018
更新日期:2016-07-28 00:00:00
abstract::Misfolded proteins of the ER are retrotranslocated to the cytosol, where they are polyubiquitinated, extracted from the membrane, and degraded by the proteasome. To investigate how the ER-associated Degradation (ERAD) machinery can accomplish retrotranslocation of a misfolded luminal protein domain across a lipid bila...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.05.048
更新日期:2016-07-14 00:00:00
abstract::The 90S pre-ribosome is an early biogenesis intermediate formed during co-transcriptional ribosome formation, composed of ∼70 assembly factors and several small nucleolar RNAs (snoRNAs) that associate with nascent pre-rRNA. We report the cryo-EM structure of the Chaetomium thermophilum 90S pre-ribosome, revealing how ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.06.014
更新日期:2016-07-14 00:00:00
abstract::Brown and beige adipocytes are specialized cells that express uncoupling protein 1 (UCP1) and dissipate chemical energy as heat. These cells likely possess alternative UCP1-independent thermogenic mechanisms. Here, we identify a secreted enzyme, peptidase M20 domain containing 1 (PM20D1), that is enriched in UCP1(+) v...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.05.071
更新日期:2016-07-14 00:00:00
abstract::Can a heterotrophic organism be evolved to synthesize biomass from CO2 directly? So far, non-native carbon fixation in which biomass precursors are synthesized solely from CO2 has remained an elusive grand challenge. Here, we demonstrate how a combination of rational metabolic rewiring, recombinant expression, and lab...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.05.064
更新日期:2016-06-30 00:00:00
abstract::Neural inputs from internal organs are essential for normal autonomic function. The vagus nerve is a key body-brain connection that monitors the digestive, cardiovascular, and respiratory systems. Within the gastrointestinal tract, vagal sensory neurons detect gut hormones and organ distension. Here, we investigate th...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.05.011
更新日期:2016-06-30 00:00:00
abstract::Antibodies to DNA and chromatin drive autoimmunity in systemic lupus erythematosus (SLE). Null mutations and hypomorphic variants of the secreted deoxyribonuclease DNASE1L3 are linked to familial and sporadic SLE, respectively. We report that DNASE1L3-deficient mice rapidly develop autoantibodies to DNA and chromatin,...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.05.034
更新日期:2016-06-30 00:00:00
abstract::Genetic screening identifies the atypical tetraspanin TM4SF1 as a strong mediator of metastatic reactivation of breast cancer. Intriguingly, TM4SF1 couples the collagen receptor tyrosine kinase DDR1 to the cortical adaptor syntenin 2 and, hence, to PKCα. The latter kinase phosphorylates and activates JAK2, leading to ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.06.009
更新日期:2016-06-30 00:00:00
abstract::Ligand-directed signal bias offers opportunities for sculpting molecular events, with the promise of better, safer therapeutics. Critical to the exploitation of signal bias is an understanding of the molecular events coupling ligand binding to intracellular signaling. Activation of class B G protein-coupled receptors ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.05.023
更新日期:2016-06-16 00:00:00
abstract::Synergistic bispecific antibodies against HIV exhibit extraordinary potency and breadth of neutralization as promising candidates for treatment and prevention. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2016.06.004
更新日期:2016-06-16 00:00:00
abstract::Transfer RNAs (tRNAs) are primarily viewed as static contributors to gene expression. By developing a high-throughput tRNA profiling method, we find that specific tRNAs are upregulated in human breast cancer cells as they gain metastatic activity. Through loss-of-function, gain-of-function, and clinical-association st...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.05.046
更新日期:2016-06-02 00:00:00
abstract::We here attempt to achieve an integrated understanding of the structure and dynamics of a number of higher-order assemblies, including amyloids, various kinds of signalosomes, and cellular granules. We propose that the synergy between folded domains, linear motifs, and intrinsically disordered regions regulates the fo...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2016.05.004
更新日期:2016-05-19 00:00:00
abstract::The recent Zika virus outbreak highlights the need for low-cost diagnostics that can be rapidly developed for distribution and use in pandemic regions. Here, we report a pipeline for the rapid design, assembly, and validation of cell-free, paper-based sensors for the detection of the Zika virus RNA genome. By linking ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.04.059
更新日期:2016-05-19 00:00:00
abstract::Telomerase is the ribonucleoprotein enzyme that replenishes telomeric DNA and maintains genome integrity. Minimally, telomerase activity requires a templating RNA and a catalytic protein. Additional proteins are required for activity on telomeres in vivo. Here, we report that the Pop1, Pop6, and Pop7 proteins, known c...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.04.018
更新日期:2016-05-19 00:00:00
abstract::Glial cells are essential components of the nervous system. In this issue, Singhvi et al. uncover cellular and molecular mechanisms through which C. elegans glia shape sensory neuron terminals and thus control animal thermosensing behaviors. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2016.04.052
更新日期:2016-05-05 00:00:00
abstract::Oncogenic activation of RAS genes via point mutations occurs in 20%-30% of human cancers. The development of effective RAS inhibitors has been challenging, necessitating new approaches to inhibit this oncogenic protein. Functional studies have shown that the switch region of RAS interacts with a large number of effect...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.03.045
更新日期:2016-04-21 00:00:00
abstract::Endophytic fungi are found within the roots of healthy plants, but their function is poorly understood. In this issue, Hiruma et al. demonstrate that, under phosphate-limiting conditions, the endophytic fungus, Colletotrichum tofieldiae, provides growth-promoting and fitness benefits to Arabidopsis, but the plant must...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2016.03.036
更新日期:2016-04-07 00:00:00
abstract::Gene duplication is a major evolutionary force driving adaptation and speciation, as it allows for the acquisition of new functions and can augment or diversify existing functions. Here, we report a gene duplication event that yielded another outcome--the generation of antagonistic functions. One product of this dupli...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.02.046
更新日期:2016-04-07 00:00:00
abstract::Activation of Agouti-related peptide (AgRP) neurons potently promotes feeding, and chronically altering their activity also affects peripheral glucose homeostasis. We demonstrate that acute activation of AgRP neurons causes insulin resistance through impairment of insulin-stimulated glucose uptake into brown adipose t...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.02.044
更新日期:2016-03-24 00:00:00
abstract::Assessing the real-world impact of biomedical research is notoriously difficult. Here, we present the framework for building a prospective science-centered information system from scratch that has been afforded by the Sidra Medical and Research Center in Qatar. This experiment is part of the global conversation on max...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.03.004
更新日期:2016-03-24 00:00:00
abstract::PD-1 immune checkpoint blockade provides significant clinical benefits for melanoma patients. We analyzed the somatic mutanomes and transcriptomes of pretreatment melanoma biopsies to identify factors that may influence innate sensitivity or resistance to anti-PD-1 therapy. We find that overall high mutational loads a...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2016.02.065
更新日期:2016-03-24 00:00:00
abstract::Most physiological functions originate with the communication between organs. Mouse genetics has revived this holistic view of physiology through the identification of inter-organ communications that are unanticipated, functionally important, and would have been difficult to uncover otherwise. This Review highlights t...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2016.02.043
更新日期:2016-03-10 00:00:00
abstract::Voluntary movement is a result of signals transmitted through a communication channel that links the internal world in our minds to the physical world around us. Intention can be considered the desire to effect change on our environment, and this is contained in the signals from the brain, passed through the nervous s...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2016.02.038
更新日期:2016-03-10 00:00:00
abstract::During development, sensory axons compete for limiting neurotrophic support, and local neurotrophin insufficiency triggers caspase-dependent axon degeneration. The signaling driving axon degeneration upon local deprivation is proposed to reside within axons. Our results instead support a model in which, despite the ap...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.01.032
更新日期:2016-02-25 00:00:00
abstract::Two-pore domain (K2P) K(+) channels are major regulators of excitability that endow cells with an outwardly rectifying background "leak" conductance. In some K2P channels, strong voltage-dependent activation has been observed, but the mechanism remains unresolved because they lack a canonical voltage-sensing domain. H...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.02.002
更新日期:2016-02-25 00:00:00
abstract::Posttranslational modifications control microtubule behavior, yet assigning roles to particular signals was hampered by lack of defined in vitro systems. In this issue of Cell, Valenstein and Roll-Mecak establish a biochemical platform to interrogate consequences of microtubule polyglutamylation, thereby providing imp...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2016.02.016
更新日期:2016-02-25 00:00:00
abstract::Repair of DNA double-strand breaks (DSBs) by non-homologous end joining is critical for neural development, and brain cells frequently contain somatic genomic variations that might involve DSB intermediates. We now use an unbiased, high-throughput approach to identify genomic regions harboring recurrent DSBs in primar...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.12.039
更新日期:2016-02-11 00:00:00
abstract::The basal ganglia (BG) are critical for adaptive motor control, but the circuit principles underlying their pathway-specific modulation of target regions are not well understood. Here, we dissect the mechanisms underlying BG direct and indirect pathway-mediated control of the mesencephalic locomotor region (MLR), a br...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.12.037
更新日期:2016-01-28 00:00:00
abstract::The central vasculature of plant roots is protected by a hydrophobic ring of endodermal cells that are enclosed by lamellae of suberin. Barberon et al. demonstrate that endodermal suberization plasticity facilitates ion homeostasis, with antithetical regulation of suberin deposition and degradation by the phytohormone...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2016.01.005
更新日期:2016-01-28 00:00:00
abstract::Malignancy can be suppressed by the immune system in a process termed immunosurveillance. However, to what extent immunosurveillance occurs in spontaneous cancers and the composition of participating cell types remains obscure. Here, we show that cell transformation triggers a tissue-resident lymphocyte response in on...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.01.002
更新日期:2016-01-28 00:00:00
abstract::During development, neurons switch among growth states, such as initial axon outgrowth, axon pruning, and regrowth. By studying the stereotypic remodeling of the Drosophila mushroom body (MB), we found that the heme-binding nuclear receptor E75 is dispensable for initial axon outgrowth of MB γ neurons but is required ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.11.047
更新日期:2016-01-14 00:00:00
abstract::Childhood asthma is typically associated with a polarized Th2 response to inhaled allergens and is influenced by genetics. Yang et al. show that the asthma susceptibility gene DENND1B controls cytokine production in Th2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes, providing a mo...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2015.12.045
更新日期:2016-01-14 00:00:00
abstract::Information processing relies on precise patterns of synapses between neurons. The cellular recognition mechanisms regulating this specificity are poorly understood. In the medulla of the Drosophila visual system, different neurons form synaptic connections in different layers. Here, we sought to identify candidate ce...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.11.021
更新日期:2015-12-17 00:00:00
abstract::Neuroinflammation is being increasingly recognized as a potential mediator of cognitive impairments in various neurological conditions. Habbas et al. demonstrate that the pro-inflammatory cytokine tumor necrosis factor alpha signals through astrocytes to alter synaptic transmission and impair cognition in a mouse mode...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2015.12.001
更新日期:2015-12-17 00:00:00
abstract::Microbial functions in the host physiology are a result of the microbiota-host co-evolution. We show that cold exposure leads to marked shift of the microbiota composition, referred to as cold microbiota. Transplantation of the cold microbiota to germ-free mice is sufficient to increase insulin sensitivity of the host...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.11.004
更新日期:2015-12-03 00:00:00
abstract::Dopamine neurons promote learning by processing recent changes in reward values, such that reward may be maximized. However, such a flexible signal is not suitable for habitual behaviors that are sustained regardless of recent changes in reward outcome. We discovered a type of dopamine neuron in the monkey substantia ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.10.063
更新日期:2015-11-19 00:00:00